Technically, one can define a part with these datums...
When measuring one simply establishes the datums as specified... So, the R .250 +/- .005 is measured after establishing a datum zero from primary datum feature A and secondary datum feature B.
The three holes Dia. .125 +/- .001 is measured from a datum reference established from datum C feature and so on. Each measurement is a separate setup.
I agree that the specifications are suspect from a design point of view. Also, I suspect that the units are inches as opposed to mm as indicated by the leading zeros usage.